Thomas Wartmann Selected Research

Ceruletide

5/2020	Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.
1/2016	Legumain is activated in macrophages during pancreatitis.
9/2015	Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis.
3/2013	Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice.
4/2010	Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype.
4/2010	Betacellulin protects from pancreatitis by activating stress-activated protein kinase.
2/2010	Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

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Thomas Wartmann Research Topics

Disease

11	Pancreatitis 05/2020 - 02/2010
5	Neoplasms (Cancer) 03/2022 - 01/2016
5	Chronic Pancreatitis 01/2016 - 05/2007
3	Necrosis 01/2016 - 04/2010
3	Inflammation (Inflammations) 01/2016 - 04/2010
2	Pancreatic Neoplasms (Pancreatic Cancer) 03/2022 - 01/2016
2	Hereditary pancreatitis 08/2013 - 05/2007
1	Adenocarcinoma 03/2022
1	Disease Progression 03/2022
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Carcinogenesis 01/2019
1	Metaplasia 01/2016
1	Atherosclerosis 01/2016
1	Stroke (Strokes) 01/2016
1	Pain (Aches) 01/2016
1	Fibrosis (Cirrhosis) 09/2015
1	Atrophy 03/2015
1	Ischemia 02/2015
1	Autoimmune Pancreatitis 03/2014
1	Autolysis 08/2013
1	Lung Injury 03/2013
1	Hypoxia (Hypoxemia) 12/2012
1	Edema (Dropsy) 04/2010
1	Ganglion Cysts (Ganglion) 11/2006

Drug/Important Bio-Agent (IBA)

7	CeruletideIBA 05/2020 - 02/2010
4	Peptide Hydrolases (Proteases)FDA Link 05/2020 - 03/2013
4	TrypsinogenIBA 05/2020 - 02/2010
3	TrypsinIBA 05/2020 - 02/2010
3	EnzymesIBA 01/2016 - 02/2010
2	Amylases FDA Link 05/2020 - 04/2010
2	CalciumIBA 01/2019 - 03/2013
2	Cathepsin BIBA 07/2016 - 03/2013
2	Kazal Pancreatic Trypsin InhibitorIBA 10/2007 - 05/2007
1	Ion Channels (Ion Channel)IBA 03/2022
1	Transient Receptor Potential ChannelsIBA 03/2022
1	Messenger RNA (mRNA)IBA 03/2022
1	Interleukin-17 (Interleukin 17)IBA 03/2020
1	CytokinesIBA 01/2019
1	Autophagy-Related Protein 5IBA 01/2019
1	CathepsinsIBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	HydrolasesIBA 07/2016
1	asparaginylendopeptidase (legumain)IBA 01/2016
1	Cysteine Proteases (Cysteine Protease)IBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	Complement C5 (Complement 5)IBA 09/2015
1	AntioxidantsIBA 03/2015
1	Autophagy-Related ProteinsIBA 03/2015
1	Fatty Acids (Saturated Fatty Acids)IBA 03/2015
1	Palm OilIBA 03/2015
1	Cardiolipins (Cardiolipin)IBA 02/2015
1	Krebs-Ringer solutionIBA 02/2015
1	Sirolimus (Rapamycin)FDA Link 03/2014
1	SteroidsIBA 03/2014
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 03/2014
1	Peptides (Polypeptides)IBA 08/2013
1	chymotrypsin CIBA 08/2013
1	Caspase 3 (Caspase-3)IBA 03/2013
1	Interleukin-6 (Interleukin 6)IBA 03/2013
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 03/2013
1	Pharmaceutical PreparationsIBA 03/2013
1	Fluorescent Dyes (Fluorescent Probes)IBA 03/2013
1	AntibodiesIBA 03/2013
1	DNA (Deoxyribonucleic Acid)IBA 01/2013
1	Transcription Factors (Transcription Factor)IBA 01/2013
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2012
1	BetacellulinIBA 04/2010
1	Protein Kinases (Protein Kinase)IBA 04/2010
1	Lipase (Acid Lipase)FDA Link 04/2010
1	Taurocholic Acid (Sodium Taurocholate)IBA 02/2010
1	Cathepsin LIBA 02/2010
1	Protein Sorting Signals (Signal Peptide)IBA 05/2007
1	Serine Proteases (Serine Protease)IBA 11/2006
1	Retinaldehyde (Retinal)IBA 11/2006

Therapy/Procedure

2	Injections 09/2015 - 03/2013
1	Therapeutics 12/2018
1	Ligation 09/2015
1	Intraperitoneal Injections 09/2015